The purpose of this study is to evaluate the relationship between the high- density lipoprotein (HDL) size distribution and levels of cholesterol and triglyceride in cord blood.
The HDL subclass was examined in 154 human cord blood sample and determinations of triglyceride, total cholesterol and HDL-cholesterol level were performed.
The results obtained were as follows:
Three distinct pattern were recognizable. The first pattern, termed the normal pattern, was distinguished by prominent double peak in the HDL,, and HDL,b regions. Minor peaks were also seen in the HDL:b and HDL, regior_s. This pattern was associated with normal lipid levels for cord blood plasma. The second pattern, termed the 2b pattern, contained a major peak in the HDL:, region, while the HDLZ HDL,,, HDL, region were less pronounced. This pattern was associated with elevated total cholesterol and HDLG levels. The third pattern, termed the 3b pattern, was characterized by a single peak in the HDLZ, region, and either relative increase in the HDL region, or increase in both HDL and HDL,. This pattern was associated with elevated triglyceride levels and decreased HDL-C levels. Although the triglyceride and cholesterol levels in the newborn are much lower than those in adults, they are seems to be the important factors associated with HDL subclass distribution. Elevated cholesterol was related toincreased particle.. in the HDL region while elevated triglyceride levels were associated with a decrease in HDLZ,+:a particle and a concomitant increase in HDL Particles.
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